Endocrine Abstracts

Objectives: Considerable evidence shows that increased serum calcium levels are associated with metabolic disorders, cardiovascular disease and increased mortality. This study investigated whether serum calcium, within a normal range, is significantly associated with serum fibrinogen and homocysteine, markers of increased cardiovascular disease risk in non-diabetic Korean subjects.Methods: A cross-sectional analysis was performed on 1096 subjects (mean a...

Beige adipocytes can be induced from white adipocytes (WAT) and precursors upon stimulation by cold temperatures and act like brown adipocytes (BAT) to increase energy expenditure. Most in vivo studies examining the mechanisms for the induction of beige/brown adipocytes have focused on subcutaneous white adipose tissue (sWAT) in the mouse. To better understand the development of beige/brown adipocytes from mammalian sWAT, we induced WAT and BAT from 3T3-L1 preadipocyt...

CDC73 (also known as HRPT2) encodes parafibromin and is known to be the causative gene of hyperparathyroidism-jaw tumor (HPT-JT) syndrome. There is no known ubiquitination of parafibromin, and the deubiquitinating enzyme (DUB) for parafibromin has not been identified to date. Full-length DUB cDNAs encoding 58 family members of ubiquitin specific proteases (USPs) were subcloned. The DUB cDNA was used to identify parafibromin interacting by yeast two-hybrid screening. W...